review of glp 1 Research shows GLP-1 drugs are effective but complex GLP-1 receptor agonists show promise

Though with similar effects as some pre-existing drugs (semaglutide, liraglutide, exenatide, etc.) targeting diabetes and obesity, tirzepatide is considered a first-in-class medication for demonstrating action on both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors

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Exendin-4 thus became the molecular blueprint for exenatide, the first twice-daily injectable GLP-1 receptor agonist, approved by the FDA in 2005